Pioglitazone enhances small-sized adipocyte proliferation in subcutaneous adipose tissue
نویسندگان
چکیده
منابع مشابه
Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients.
OBJECTIVES To examine the in vivo effects of highly active antiretroviral therapy (HAART) regimens on adipose tissue mitochondrial DNA (mtDNA) depletion, mitochondrial organellar proliferation, and markers of adipocyte differentiation and phenotype. DESIGN AND METHODS DNA and mRNA quantification using real-time PCR methods was performed on adipose tissue samples from 31 HIV-infected individua...
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Human adipose tissue represents an abundant, practical and appealing source of donor tissue for autologous cell replacement. Recent findings have shown that stem cells within the stromalvascular fraction of adipose tissue display a multilineage developmental potential. Adipose tissue-derived stem cells can be differentiated towards adipogenic, osteogenic, chondrogenic,myogenic and neurogenic li...
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The developments in the technologies based on the use of autologous adipose tissue attracted attention to minor depots as possible sampling areas. Some of those depots have never been studied in detail. The present study was performed on subcutaneous adipose depots sampled in different areas with the aim of explaining their morphology, particularly as far as regards stem niches. The results dem...
متن کاملPioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo.
Thiazolidenediones such as pioglitazone improve insulin sensitivity in diabetic patients by several mechanisms, including increased uptake and metabolism of free fatty acids in adipose tissue. The purpose of the present study was to determine the effect of pioglitazone on mitochondrial biogenesis and expression of genes involved in fatty acid oxidation in subcutaneous fat. Patients with type 2 ...
متن کاملAdipocyte turnover and adipose morphology ADIPOCYTE TURNOVER: RELEVANCE TO HUMAN ADIPOSE TISSUE MORPHOLOGY Running head: Adipocyte turnover and adipose morphology
Department of Medicine, Karolinska Institutet at Karolinska University Hospital, 141 86, Stockholm, Sweden, Institute for Theoretical Biology (ITB), Humboldt University Berlin and Charité, Invalidenstrasse 43, 10115 Berlin, Germany, Department of Cell and Molecular Biology, Karolinska Institutet, 171 77 Stockholm, Sweden, Department of Mathematics, Stockholm University, 106 91 Stockholm, Sweden...
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2012
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.ej12-0259